Does bariatric surgery reduce inflammatory activation in obesity? Evidence from the C5a fraction of complement
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Introduction: Obesity is a state of low-grade chronic inflammation that plays a central role in the genesis of several metabolic and cardiovascular comorbidities. Among the mediators of this process, the complement system stands out, whose activation decisively contributes to the perpetuation of the inflammatory response. Objective: To review the changes in serum concentration of the C5a fraction of the complement system in obese patients undergoing Roux-en-Y gastric bypass, and to investigate its possible correlation with changes in metabolic parameters. Method: Integrative review based on online research in virtual platforms using the DECs descriptors "complement, C5a, obesity and inflammation" related to the topic, with AND or OR search, considering the title and/or abstract. The material for reading and analysis was selected from the SciELO, Google Scholar, PubMed and Scopus platforms. Result: Considering only those with the greatest relevance to the topic, 31 articles were read in full. Conclusion: Bariatric surgery significantly reduces serum C5a levels, suggesting attenuation of inflammatory activation mediated by the complement system
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