Non-neoplastic hematological diseases in Brazil: profile ofhospitalizations and main causes
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Abstract
Introduction: Hematological diseases are disorders that affect the blood, bone marrow and lymphatic system, impairing the production or functioning of blood cells. They contribute negatively to morbidity and mortality, overloading health systems due to the need for continuous treatment.
Objective: To characterize the profile of patients with hematological diseases treated at a university hospital between 2018 and 2024, through principal component analysis.
Method: This is a descriptive and retrospective study based on secondary data of hospitalized patients with hospitalization diagnoses classified in groups D50 to D89 of the 10th Revision of the International Classification of Diseases.
Results: A total of 1,076 hospitalizations for non-neoplastic hematological diseases were recorded. There was a predominance of men (51%). Recovery was high (88%), while deaths and transfers added up to 12%. In the principal component analysis, five groups were identified that together explain 72.2% of the total variance.
Conclusion: The profile of hematological patients is not homogeneous and the classification into five groups is important for university hospitals to optimize human and financial resources, as well as outpatient and high-complexity follow-up in the SUS.
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References
Thachil J, Owusu-Ofori S, Bates I. Haematological Diseases in the Tropics. Manson's Tropical Infectious Diseases. 2014:894-932.e7. https://doi.org/10.1016/b978-0-7020-5101-2.00066-2
Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123(5):615-24. https://doi.org/10.1182/blood-2013-06-508325
Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad Sci. 2019;1450(1):15-31. https://doi.org/10.1111/nyas.14092
Safiri S, Kolahi AA, Noori M, Nejadghaderi SA, Karamzad N, Bragazzi NL, et al. Burden of anemia and its underlying causes in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019. J Hematol Oncol. 2021;14(1):185. https://doi.org/10.1186/s13045-021-01202-2
Ministério da Saúde. Datasus. Morbidade hospitalar do SUS – por local de internação – Brasil. 2025. Disponível em: http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sih/cnv/niuf.def
GBD 2021 Anaemia Collaborators. Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021. Lancet Haematol. 2023;10(9):713-34. https://doi.org/10.1016/s2352-3026(23)00160-6
Milagres CS, Moraes KBD, Franceschini SCC, Sant’Ana LFR, Lima LM, Ribeiro AQ. Prevalência e fatores associados à presença de anemia em idosos do município de Viçosa (MG), Brasil. Ciênc Saúde Coletiva 2015; 20(12):3733-741. http://doi. org/10.1590/1413-812320152012.20752014
Organização Mundial da Saúde. CID-10: classificação estatística internacional de doenças e problemas relacionados à saúde. São Paulo: EDUSP, 2014.
Obregon PL, Kupka FS, Espinoza-Quinones FR. Interpretação dos dados de óbitos durante a pandemia de COVID-19 pela estatística multivariada ACP, em um hospital no município de Cascavel-PR. RSPP. 2024;7(1):1-28. https://doi.org/10.32811/25954482-2024v7n1.865
The jamovi project (2022). jamovi. (Version 2.3) [Computer Software]. Retrieved from https://www.jamovi.org.
Kaiser HF. The varimax criteria for analytical rotation in factor analysis. Psychometrica, 23: 141-51, 1958.
Muñoz RLS, Lucena GR, Grigório MC, Eto LY. Prevalência de anemia em idosos internados em enfermarias gerais de um hospital universitário. RBCEH, Passo Fundo. 2016;13(1): 25-34. https://doi.org/10.5335/rbceh.v13i1.5424
Silva DG, Araújo MCS, Bevilaqua LT, Colpo E. Fatores associados com a presença de anemia em pacientes hospitalizados. Revista da AMRIGS. 2022;66(1):194-8.
Machado ÍE, Malta DC, Bacal NS, Rosenfeld LGM. Prevalência de anemia em adultos e idosos brasileiros. Rev Bras Epidemiol. 2019;(Suppl 02):E190008. https://doi.org/10.1590/1980-549720190008.supl.2
Sousa NDS, Menezes TN, Silva NA, Eulálio MC, Paiva AA. Prevalência de anemia e correlação da concentração de hemoglobina com fatores cognitivos em idosos. Ciênc Saúde Coletiva. 2018;23(3):935-44. https://doi.org/10.1590/1413-81232018233.09082016
Rodrigues RDR, Brunetta DM, Costa L, Benites BD, Magnus MM, Alves SOC, et al. Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Anemia tolerance mechanisms. Hematol Transfus Cell Ther. 2024;46 (Suppl 1):77-82. https://doi.org/10.1016/j.htct.2024.02.010
Mendes IL, Duarte MFR, Figueredo FG. Etiopatogenia e repercussões clínicas da anemia nos idosos: revisão de literatura. In: Tópicos nas ciências da saúde: Organizadora Aris Verdecia Peña. – Nova Xavantina, MT: Pantanal, 2022. https://doi.org/10.46420/9786581460587
Geisel T, Martin J, Schulze B, Schaefer R, Bach M, Virgin G, et al. An etiologic profile of anemia in 405 geriatric patients. Anemia. 2014;2014:932486. https://doi.org/10.1155/2014/932486
Thomson AM, McHugh TA, Oron AP, Teply C, Lonberg N, Tella VV, et al. Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021. The Lancet Haematology. 2023;10:585-99
Ferreira WFS, Oliveira EM, Dutra DA. Impactos epidemiológicos em hospitalizações por patologias do sangue e dos órgãos hematopoéticos na 4ª regional de saúde do Estado do paraná entre 2017 a 2021. Society and Development, 2023;12(3):e26912340747. https://doi.org/10.33448/rsd-v12i3.40747
Loureiro MM, Rozenfeld S. Epidemiologia de internações por doença falciforme no Brasil. Rev Saúde Pública 2005:39(6):943-9. https://doi.org/10.1590/S0034-89102005000600012
Oliveira LC, Ramos KDS, Oliveira BAC. Perfil de mortalidade por doenças hematológicas não neoplásicas em crianças e adolescentes no estado do Rio de Janeiro entre 2015 a 2020. Hematol Transfus Cell Ther. 2022;44(S2):S1−S689. http://doi.org/10.1016/j.htct.2022.09.603
Hamaerschlak N, Maluf E, Pasquini R, Eluf-Neto J, Moreira FR, Cavalcanti AB et al. Incidence of aplasic anemia and agranulocytosis in Latin America – The LATIN study. São Paulo Med J. 2005; 123(3):101-4. https://doi.org/10.1590/S1516-31802005000300002
Vilela TS, Areco KN, Braga JAP. Mortalidade por aplasia de medula óssea no Brasil de 2000 a 2019. Evidência do mundo real. Hematology, Transfusion and Cell Therapy, 2022: 44: S334, supl. 2. https://doi.org/10.1016/j.htct.2022.09.565
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Especializada e Temática. Perfil das coagulopatias hereditárias: Ministério da Saúde, Secretaria de Atenção à Saúde. Departamento de Atenção Especializada e Temática. – Brasília: Ministério da Saúde, 2018. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/perfil_coagulopatias_hereditarias_2026.pdf
Capovilla E, Gonçalves MS, de Oliveira AFB, Ruschel RN, de castro MY, Vianna MZ et al. Epidemiologia das internações para tratamento de hemofilia no Brasil de janeiro de 2020 a janeiro de 2025. hematol transfus cell ther. 2025;47(S3):104901. https://doi.org/10.1016/j.htct.2025.104929
Moura VC, dos Santos CF, dos Santos AFS. Anemia hemolítica autoimune. Ciências Biológicas, 2024;28:134/MAI. http://doi.org/10.5281/zenodo.11361259
Ramos ABA, Ribeiro AJ, Delfino KKS, Almeida LS, da Silva AL. Anemia hemolítica autoimune: uma revisão integrativa. e-Acadêmica. 2022;3(2):e8932258. https://doi.org/10.52076/eacad-v3i2.258
Nascimento CVCD, Farias DSR, Feio ECG, Rocha HOA, Shinkai A, Brandão AS, Franco SC. Mortalidade por anemia hemolítica adquirida no Brasil (2010-2019). hematol transfus cell ther. 2021;43(S1):S1−S546. https://doi.org/10.1016/j.htct.2021.10.042