Como acelerar a reparação de feridas cutâneas? Evidências com células-tronco e membrana amniótica
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Resumo
Introdução: A pele desempenha papel fundamental como barreira biológica, atuando na proteção do organismo contra agentes físicos, químicos e microbiológicos do meio externo. Nesse contexto, abordagens fundamentadas na engenharia de tecidos têm sido amplamente investigadas, especialmente aquelas que combinam o emprego de células-tronco e biomateriais, como a membrana amniótica.
Objetivo: Esta revisão teve como objetivo analisar criticamente as evidências disponíveis na literatura acerca dos efeitos da aplicação de células-tronco mononucleares derivadas da medula óssea, isoladamente ou em associação à membrana amniótica descelularizada.
Método: Revisão integrativa conduzida com rigor metodológico, reunindo evidências para a prática clínica. Foi realizada nas bases de dados PubMed e Medline, utilizando o operador booleano "AND" para associar descritores relevantes.
Resultado: Foram incluídos 97 artigos que continham relação com os descritores referidos.
Conclusão: Os achados demonstram que as células-tronco mononucleares associadas à membrana amniótica melhoram a cicatrização em fases mais tardias da reparação, podendo gerar menos fibrose, melhor qualidade estética e funcional da cicatriz.
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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