O papel da obesidade (e da perda de peso pela cirurgia bariátrica) nas doenças autoimunes
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Resumo
Introdução: A obesidade tem sido ligada ao aparecimento ou piora de doenças autoimunes.
Objetivo: Revisar a presença de autoanticorpos em obesos submetidos à cirurgia bariátrica e verificar a possível alteração deste perfil após o procedimento cirúrgico.
Método: Revisão narrativa da literatura efetuada no PubMed e Scielo. A busca utilizou as palavras-chave: “obesidade, autoimunidade, fator antinuclear, cirurgia bariátrica”. Os critérios de inclusão compreenderam artigos de revisão, estudos experimentais, pesquisas pré-clínicas e clínicas, escritos em português e inglês e disponíveis em texto completo.
Resultado: Foram incluídos 63 artigos.
Conclusão: Existe alta prevalência de FAN positivo na população obesa e candidata à cirurgia bariátrica que diminui consideravelmente no pós-operatório. O mesmo não pode ser verificado com o fator reumatóide, anticorpos do perfil ENA e anti-ds DNA, anticorpos anticardiolipina IgG e IgM, e anticorpos anti-endomísio. Nenhuma variável clínica ou antropométrica pôde ser ligada à presença de autoanticorpos, salvo níveis de vitamina D que foram significativamente menores nos indivíduos em pré-operatório e FAN positivos.
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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